Design and Invitro Studies of a Needle-Type Glucose Sensor for Subcutaneous Monitoring - Bindra, D.S.; Zhang, Y.N.; Wilson, G.S.; Sternberg, R.; Thevenot, D.R.; Moatti, D.; Reach, G. (Analytical Chemistry, 1991)
A new miniaturized glucose oxidase based needle-type glucose microsensor has been developed for subcutaneous glucose monitoring. The sensor is equivalent in shape and size to a 26-gauge needle (0.45-mm o.d.) and can be implanted with ease without any incision. The novel configuration greatly facilitates the deposition of enzyme and polymer films so that sensors with characteristics suitable for in vivo use (upper limit of linear range > 15 mM, response time < 5 min, and sensitivity yielding a 5:1 signal-to-background ratio at normal basal glucose levels) can be prepared in high yield (> 60%). The sensor response is largely independent of oxygen tension in the normal physiological range. It also exhibits good selectivity against common interferences except for the exogenous drug acetaminophen.
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