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2021-11-23 11:11:25 www.mdpi.com http://creativecommons.org/licenses/by/3.0/ emerging contaminants high-resolution mass spectrometry micropollutant fingerprint non-target screening solid phase extraction statistical analysis urban waters Evaluation of Sample Preparation Methods for Non-Target Screening of Organic Micropollutants in Urban Waters Using High-Resolution Mass Spectrometry Non-target screening (NTS) has gained interest in recent years for environmental monitoring purposes because it enables the analysis of a large number of pollutants without predefined lists of molecules. However, sample preparation methods are diverse, and few have been systematically compared in terms of the amount and relevance of the information obtained by subsequent NTS analysis. The goal of this work was to compare a large number of sample extraction methods for the unknown screening of urban waters. Various phases were tested for the solid-phase extraction of micropollutants from these waters. The evaluation of the different phases was assessed by statistical analysis based on the number of detected molecules, their range, and physicochemical properties (molecular weight, standard recoveries, polarity, and optical properties). Though each cartridge provided its own advantages, a multilayer cartridge combining several phases gathered more information in one single extraction by benefiting from the specificity of each one of its layers. 7064 10.3390/molecules26237064 https://www.mdpi.com/1420-3049/26/23/7064 en Number: 23 2021/1 26 23 Molecules Multidisciplinary Digital Publishing Institute NinaHuynh EmilieCaupos Caroline Soares Peirera JulienLe Roux AdèleBressy Régis Moilleron